2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Carbonyl Reductase

Carbonyl Reductase 

Carbonyl reductase

Carbonyl reductase, an NADPH-dependent oxidoreductase, catalyzes the reduction of aldehydes and ketones to primary and secondary alcohols, respectively. This enzyme exhibits broad substrate specificity for various endogenous and xenobiotic carbonyl compounds, facilitating the reduction of endogenous prostaglandins, steroids, and other aliphatic aldehydes and ketones. Carbonyl reductases belong to the short-chain dehydrogenases/reductases (SDR) family. Among them, CBR1 plays a crucial role in protecting cells from oxidative stress-induced damage and is extensively studied for its involvement in drug metabolism, particularly in converting the chemotherapeutic agent Doxorubicin into the cardiotoxic metabolite Danurubicin. Additionally, CBR3, a target gene of the Nrf2 transcription factor, is implicated in inflammatory responses[1][2][3].

Carbonyl Reductase 相关产品 (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155587
    Hydroxy-PP Inhibitor 99.66%
    Hydroxy-PP 是一种有效的羰基还原酶 1 (CBR1) 抑制剂，IC50 值为 0.78 μM。Hydroxy-PP 还有效抑制细胞质酪氨酸激酶 Fyn，IC50 值为 5 nM。
    Hydroxy-PP
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z