2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Carbonyl Reductase

Carbonyl Reductase 

Carbonyl reductase

Carbonyl reductase, an NADPH-dependent oxidoreductase, catalyzes the reduction of aldehydes and ketones to primary and secondary alcohols, respectively. This enzyme exhibits broad substrate specificity for various endogenous and xenobiotic carbonyl compounds, facilitating the reduction of endogenous prostaglandins, steroids, and other aliphatic aldehydes and ketones. Carbonyl reductases belong to the short-chain dehydrogenases/reductases (SDR) family. Among them, CBR1 plays a crucial role in protecting cells from oxidative stress-induced damage and is extensively studied for its involvement in drug metabolism, particularly in converting the chemotherapeutic agent Doxorubicin into the cardiotoxic metabolite Danurubicin. Additionally, CBR3, a target gene of the Nrf2 transcription factor, is implicated in inflammatory responses[1][2][3].

Carbonyl Reductase 亚型特异性产品:

Carbonyl Reductase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155587
    Hydroxy-PP Inhibitor 99.66%
    Hydroxy-PP 是一种有效的羰基还原酶 1 (CBR1) 抑制剂，IC50 值为 0.78 μM。Hydroxy-PP 还有效抑制细胞质酪氨酸激酶 Fyn，IC50 值为 5 nM。
    Hydroxy-PP
  • HY-121710
    MonoHER Inhibitor
    MonoHER (7-Monohydroxyethylrutoside) 是一种 CBR1 抑制剂，可作为心脏保护剂。MonoHER 浓度依赖性抑制 CBR1 V88 和 CBR1 I88 的活性。
    MonoHER
  • HY-RS28634
    Cbr3 Rat Pre-designed siRNA Set A
    Cbr3 Mouse Pre-designed siRNA Set A 包括针对 Cbr3 (Rat) 基因的不同区域设计三对 siRNA，以及阴性对照、FAM 标记阴性对照和阳性对照。
    Cbr3 Rat Pre-designed siRNA Set A
    Cbr3 Rat Pre-designed siRNA Set A
Carbonyl Reductase Isoform Comparison

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